About Fiona and Matt Kesby Of GO Virtual Assistants

Our Founder and Chief Technology Officer Matt Kesby is experienced in developing employees and organizations to produce outstanding results. He has developed 7 different ventures, created employment for over 500 people and served more than 1.1 million customers in Australia. In addition to prestigious awards, his accolades also include a Bachelor of Business majoring in Marketing with postgraduate studies in Strategy and Innovation and a 10-year membership with the global community Entrepreneurs Organization. Matt was Execution Practice Leader for FranklinCovey Australia, assisting companies to coach their employees with the methodologies of The 4 Disciplines of Execution and The Seven Habits of Highly Effective People.

Before joining GO-VA, our CEO and Head of Culture Fiona Kesby built a track record in recruitment, including the IT and construction and engineering industries. She relocated to Cebu with her 2 daughters in May 2015, a year into GO-VA’s journey, to lead Sales and Recruitment. That soon expanded into taking the helm as CEO. Fiona is committed to “getting the culture right” as the basis for GO-VA’s growth and the well-being and performance of all team members. In 2018, inspired by a Zappos culture camp led by Tony Hsieh, Fiona introduced the position of Chief Happiness Officer in GO-VA.

What is Beta Thalassemia?

What is Beta Thalassemia?

Beta-thalassemia (β-thal) is a blood-related disorder and occurs when the body cannot make enough of the protein called hemoglobin (present in red blood cells; RBCs). Due to the lack of hemoglobin in RBCs, they cannot function properly and persist for shorter periods. It occurs due to mutations in the HBB gene on chromosome 11, also inherited in an autosomal, recessive fashion. The severity of the disease depends on the nature of the mutation and the presence of mutations in one or both alleles. Sex-related bias is generally not apparent in β-thal.

How many types of Beta Thalassemia?

There are three different types of β-thalassemia; β-thal minor, β-thal intermediate and β-thal major. Other than these, there are some more classes viz; Hemoglobin E β-thal, Sickle β-thal, Hemoglobin C – β-thal, Hereditary persistence of fetal hemoglobin (HPFH) associated with β-thal, Dominant β-thal, Trichothiodystrophy (TTD) and X-linked thrombocytopenia with thalassemia (XLTT). The thalassemia spectrum is clinically divided into two main categories based on the patient’s need for blood transfusion—transfusion-dependent thalassemia (TDT) and non-transfusion dependent thalassemia (NTDT).

The number of foreign-born residents in the United States has increased over the last five decades from 5.4% in 1960 to nearly 13% in 2010. In 2010, 53% and 28% of foreign-born United States residents had immigrated from Latin America and Asia, respectively. Americans of Hispanic and African descent are also at risk of thalassemia. In England approximately, 2,800 (0.44%) carry beta-thalassemia trait annually, and 43 (0.07/1,000) are affected by beta-thalassemia major.

What is Beta Thalassemia Market Outlook?

Beta Thalassemia is a genetic disorder which is inherited in an autosomal, recessive fashion. The clinical manifestations seen in patients are severe anemia, abnormal hemoglobin and buildup of iron in the body. Excess iron can damage the heart, liver, and endocrine system. Being a genetic disorder there is no specific treatment for Beta Thalassemia and the treatment regimen mainly focus on delaying progression of the disease and relieving the symptoms.

Blood transfusion and iron chelation are the standard of care for patients with TDT, with the former suppressing ineffective hematopoiesis and its complications, and the latter treating and preventing complications from iron overload. The goal of treatment is to maintain a hemoglobin level of 9-10.5 g/dL, which has been shown to promote normal growth, suppress bone marrow activity, and minimize iron accumulation.

The main complication from frequent blood transfusions is iron overload, as the human body lacks a method of excreting excess iron. Accumulation of iron in the body, particularly in the heart, liver, and pituitary gland, can lead to heart failure, cirrhosis, hepatocellular carcinoma, hypothyroidism, hypoparathyroidism, hypogonadism, diabetes, and growth failure. Iron chelation therapy is the main method of both treating and preventing iron overload.

The primary goal of chelation is to maintain iron balance in the body by excreting excess iron through urine or feces. Thus, owing to the symptomatic treatment in target patient population, the current market of Beta Thalassemia covered in the report solely focuses on the market revenue generated by iron binders/chelators. There are some iron chelators used in iron chelation therapies, namely: Deferoxamine (DFO), Deferiprone (DFP) and Deferasirox (DFX). These are either given alone or in combination Desferal (deferoxamine mesylate USP), developed by Novartis, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration.

Desferal is indicated for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependent anemia. Desferal can promote iron excretion in patients with secondary iron overload from multiple transfusions—as may occur in the treatment of some chronic anemias, including thalassemia. Besides, it can be given by intramuscular, subcutaneous, and intravenous routes of administration.

Novartis developed Exjade (Deferasirox), which is an oral iron chelator approved by the US FDA in 2005. Its main use is to reduce chronic iron overload in patients who are receiving long term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.

It is a member of a new class of tridentate iron chelators, the N-substituted bis-hydroxyphenyl-triazoles. Metabolism and elimination of deferasirox are primarily by glucuronidation followed by hepatobiliary excretion into the feces. Approved in more than 70 countries including the US and Europe, Exjade is the first once-daily oral iron chelator approved for use in patients with chronic transfusional iron overload who have a wide range of underlying anemias.

Help Your Business to Grow With Advertising Translation Services

And for that, hiring a quality translator who can convey your message to your audience of different countries through advertisement and brand promotion in their language. In today’s era, every business is reaching out to their target audience of different countries who speak different languages with their vision, ideas, products, and services. But you can’t do this all alone, as you don’t know the various languages but a translator does and they can help you with this.

You can choose any of the accurate advertising translation services that you find best for your business. There are many other benefits of opting for translation services, like:

Your Business Stands Out In The Market: While other businesses will only be targeting only their local market, you will be targeting the global market.
Unique Image Of Your Business In The Market: Your strategy of targeting the global market with the help of translation services, builds the unique image of your business.
Enhances The Visibility Of Marketing Campaigns: Your advertising and marketing campaign needs a translator most as only then can the people who speak other languages get to know about your brand, products, and services and it will be promoted globally. And hence, you should not be afraid of investing in a translator as it’s an investment for your business.
With these many benefits, your business’ revenue generation increases, and also your brand awareness increases as now you target various and larger audiences.

Small Company Marketing Consultants – Why You Need One And How To Select One

Having spent many years working with small and midsized B2B and B2C organizations on their marketing and marketing communications strategies and plans, I believe I’ve got a good sense of the issues facing them. Generally, at the top of the list, is the lack of a real marketing plan. How is it possible that something so basic is missing? My conclusion is that, despite possessing the skill sets that drive their organization’s success, founders and/or management simply do not have:

Time to think about marketing at all, because there is always something “more important or urgent” that needs their attention;
A real understanding of the power of marketing and how it can significantly improve profits and return on investment (ROI);
The resources, budgets and people available – marketing and marketing communications is “unfamiliar and scary”, and there are always other areas that need support first;
The knowledge of how to seek out and evaluate professional marketing help.
These are concerns regardless of the type of organization – start up, early stage or established companies, and even nonprofits for that matter. And, without real planning upfront, many brands are operating with a “Ready, Fire, Aim” reaction to the marketplace.

What Will Hiring A Marketing Or Marketing Communications Professional Do For You?

In order to accomplish short and long-term objectives you need to develop a meaningful marketing strategy and an integrated marketing communications plan and tactics. At its core, having a professional marketing program will improve a brand’s profitability and ROI. This task is often outsourced, frequently with a part-time Chief Marketing Officer.

The process starts with the outside consultant learning about the brand – its strengths and weaknesses, competition, distribution, business plan objectives, existing communication materials, employee involvement. During this learning period, the consultant also avails himself of any pertinent primary or secondary research. Most important, this period is also the time for establishing trust between the organization and the consultant.

While some tasks may be completed directly during this learning period, an outside professional would use this knowledge to prepare:

1. A marketing and marketing communications strategy, along with a positioning statement. The positioning statement is a succinct description of the core target audience to whom the brand is directed, and a compelling picture of how the marketer wants the audience to view the brand.

Sound simple? Take a minute and answer these four questions about your brand:

The target audience, in very specific detail?
The category in which the brand competes, and its relevance to customers?
The brand’s benefit and point of difference?
A reason for the customer to believe – the most compelling proof?
The positioning statement is the credo for the brand to live by. All marketing and marketing communications should flow from this positioning and be understood by all employees, agents, partners and management.

2. An integrated and holistic plan with tactical expressions – media programs; creative executions, including new and/or traditional advertising; public relations; content marketing (social media, articles, blogs, white papers, video); packaging; point of purchase; employee engagement; and, events.

The use of internal or external staff to create the above will be directed and evaluated by the consultant or, if necessary, specialists may be recommended.

3. Recommendations for primary or secondary research when clear cut answers don’t exist on specific subjects. Marketing depends on a complete understanding of the customers’ “wants and needs” as well as how they relate to your brand and competition. Not just what your staff thinks; rather, information. Facts beat opinion every time.

4. A procedure of measurement and evaluation of the objectives of the agreed upon plan, as well as the established objectives to be accomplished with each target audience and marketing communication task. Benchmarking and on-going analysis is key to successful marketing programs, allowing for change or refinement as you proceed.

5. A format for informing and discussing the reasoning behind the marketing planning, so that everyone in the organization understands why the specific strategies, plans and tactics were developed and implemented. The consultant becomes a “teacher” and the entire organization becomes brand advocates.

Marketing consultants have increasingly become members of the C-Suite because of today’s turbulent and rapidly changing environment.

What Talents Should A Marketing Consultant Have?

Look for a consultant, full or part-time, who is:

1. Willing to learn your business from the ground up and doesn’t have a “one size fits all” mentality;

2. An established professional, with extensive experience across industries and brands in B2B, B2C and nonprofit organizations, large and small. Expand your horizons and don’t settle for experience in only your niche or industry;

3. Media neutral and willing to embrace analytics to develop a variety of programs as well as to measure them. In today’s complicated marketplace, a consultant must understand new and traditional media, the difference between efficiency and effectiveness, “likes” vs. “sales”, the dangers of digital ad fraud, etc., etc.;

4. Apolitical and willing to tell it like it is, so candor will flourish in your relationship. Having your consultant free to demonstrate the discipline of marketing and marketing communications will build trust and a meaningful partnership;

5. Has an established network of marketing communications specialists who can be called in to provide solutions when necessary.

The marketing and marketing communications strategic and tactical challenges of today are growing exponentially. But, as with our uncertain economic and political environment, putting your head in the sand isn’t a viable response. As Will Rogers said, “Even if you’re on the right track, you’ll get run over if you just sit there.”

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